Ellagic acid, sulforaphane, and ursolic acid in the prevention and therapy of breast cancer: current evidence and future perspectives

Globally, breast cancer is the most common cancer and the second leading cause of cancer-related death among women. Surgery, chemotherapy, hormonal therapy, and radiotherapy are currently available treatment options for breast cancer therapy. However, chemotherapy, hormonal therapy, and radiotherapy are often associated with side effects and multidrug resistance, recurrence, and lack of treatment in metastasis are the major problems in the treatment of breast cancer. Recently, dietary phytochemicals have emerged as advantageous agents for the prevention and therapy of cancer due to their safe nature. Ellagic acid (EA), sulforaphane (SF), and ursolic acid (UA), which are found in widely consumed fruits and vegetables, have been shown to inhibit breast cancer cell proliferation and to induce apoptosis. This review encompasses the role of EA, SF, and UA in the fight against breast cancer. Both in vitro and in vivo effects of these agents are presented.

https://www.researchgate.net/publication/324783782_Ellagic_acid_sulforaphane_and_ursolic_acid_in_the_prevention_and_therapy_of_breast_cancer_current_evidence_and_future_perspectives 

Diabetes and red blood cell parameters

Type 2 diabetes is a common disease in these days and day by day it is arising. The main focus of the study was to investigate association of packed cell volume (PCV), Mean Corpuscular Volume (MPV), Mean Corpuscular Hemoglobin Concentration (MCHC), Red Cell Distribution Width (RDW) with glycemic marker HbA1c. So that PCV, MPV, MCHC, RDW could be used as a predictor of glucoregulation in type 2 diabetes instead of HbA1c value. This study included 87 DMT2 patients, which divided into two groups, A (n=41, presence in diabetics≤6.5-6.9%) and B (n=46, target in diabetes≥7.0%), according to HbA1c values. Spearsman correlation co-effi cients were calculated to evaluate the relationship between RBC count, MCHC, RDW with random blood sugar (RBS) and PCV, MCV, MCHC with HbA1c value. Binominal logistic regression analysis was performed to estimate the relationship between glycemic control, as dichotomous outcome of MCHC, RDW, PCV, and MCV as the main prognosticator. MCHC and RDW were signifi cantly higher in the group B compared to the group A. RDW and MCHC may be applied as the auxiliary indicators of deterioration of glucoregulation.

Md Sadikuj Jaman: Association of Mean Platelet Volume and Platelet D...

Md Sadikuj Jaman: Association of Mean Platelet Volume and Platelet D...: Diabetes mellitus type 2 (DMT2) is a metabolic disorder, and its prevalence is rising worldwide. The objective of the study was to invest...

Md Sadikuj Jaman: Fresh mango and commercial mango juices contain va...

Md Sadikuj Jaman: Fresh mango and commercial mango juices contain va...: Fresh mango and commercial mango juices contain various natural antioxidants which have beneficial health effects. In this study, we com...

Fresh mango and commercial mango juices contain various natural antioxidants which have beneficial health effects. In this study, we compared total antioxidant activity of fresh mango (fazlee, amrapali, mohanvog, langra, and gopalvog) juices with that of commercial mango juices (pran frooto, sezan, frutika, and sundrop mango fruit drink), which are available in Bangladesh. Total antioxidant activity was measured by DPPH method. Enzymatic browning in fresh and commercial mango juices was determined by tyrosinase inhibitory assay. The IC50 values of fazlee, amrapali, mohanvog, langra, gopalvog, pran frooto, sezan, frutika, sundrop mango fruit drink juices, vitamin C, and vitamin E were 1.159, 1.367, 0.575, 1.675, 0.725, 0.435, 1.025, 0.925, 0.678, 0.057, and 0.039 mg/ml, respectively. No sample shows tyrosinase inhibitory activity. In conclusion, commercial mango juices can be considered as a good source of antioxidant

https://www.researchgate.net/publication/321392599_Comparison_of_total_antioxidant_activity_between_fresh_and_commercial_mango_juices_available_in_Bangladesh 

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Association of Mean Platelet Volume and Platelet Distribution Width with Hba1c

Diabetes mellitus type 2 (DMT2) is a metabolic disorder, and its prevalence is rising worldwide. The objective of the study was to investigate association of mean platelet volume (MPV) and platelet distribution width (PDW) with glycemic control marker HbA1c. So that MPV, PDW could be used as a prognosticators of deterioration of glucoregulation in diabetes mellitus type 2 instead of HbA1c value. This study included 87 DMT2 patients, which divided into two groups, A (n=41, presence in diabetics ≤ 6.5 – 6.9%) and B (n=46, target in diabetes ≥ 7.0%), according to HbA1c values. Spearsman correlation co-efficients were calculated to evaluate the relationship between MPV, PDW and HbA1c value. Binominal logistic regression analysis was performed to estimate the relationship between glycemic control, as dichotomous outcome of MPV and PDW as the main prognosticator. MPV and PDW were significantly higher in the group B compared to the group A. Significant positive correlations of MPV with Random Blood Sugar (RBS) and HbA1c value were found in the total sample. MPV and PDW correlate with glycemic control markers in DMhttps://www.researchgate.net/publication/320172574_Association_of_Mean_Platelet_Volume_and_Platelet_Distribution_Width_with_Hba1c